Spirulina is a superior nutraceutical for combating the ill effects of unhealthy lifestyle patterns increasingly prevalent in urban and semi-urban India, including sedentary behavior, poor dietary choices, chronic stress, tobacco/alcohol use, and sleep deprivation. These factors contribute cumulatively to the growing incidence of obesity, type 2 diabetes, cardiovascular disease, metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD). Spirulina offers a multifaceted intervention through its rich profile of complete protein, essential fatty acids (e.g., GLA), vitamins (notably B-complex and provitamin A), minerals (iron, magnesium, zinc), antioxidants (phycocyanin, SOD, β-carotene), and anti-inflammatory compounds, which together improve metabolic regulation, immune function, lipid profile, and oxidative balance (Khan et al., 2005; Riss et al., 2007). Clinical studies have shown that Spirulina supplementation improves lipid metabolism, insulin sensitivity, liver enzyme levels, and reduces C-reactive protein (CRP) and oxidative markers such as malondialdehyde (MDA) in adults with lifestyle-related metabolic disorders (Mazokopakis et al., 2014; Parikh et al., 2001). Moreover, its adaptogenic properties aid in managing mental fatigue and chronic stress, while enhancing gut microbiota and energy metabolism, making it highly effective in reversing or preventing systemic derangements induced by a modern unhealthy lifestyle. Given its broad-spectrum efficacy and excellent safety, Spirulina stands as a gold-standard natural supplement for lifestyle disease prevention and reversal in India.