Spirulina is a best-in-class natural supplement for mitigating the systemic damage caused by chronic smoking and alcohol consumption, particularly in India, where tobacco and alcohol use contribute significantly to the national burden of non-communicable diseases. Smoking introduces high levels of free radicals and reactive oxygen species (ROS), leading to oxidative DNA damage, endothelial dysfunction, and pulmonary inflammation. Likewise, chronic alcohol intake disrupts hepatic detoxification, causes lipid peroxidation, and impairs nutrient absorption. Spirulina's rich antioxidant matrix—comprising phycocyanin, superoxide dismutase (SOD), β-carotene, vitamin E, glutathione, and selenium—has been shown to neutralize tobacco- and ethanol-induced oxidative stress, enhance detoxification enzymes, and reduce lipid peroxidation markers such as malondialdehyde (MDA) (Premkumar et al., 2001; El-Desoky et al., 2013). Preclinical studies confirm that Spirulina ameliorates alcohol-induced hepatotoxicity, improves liver function tests (ALT, AST), and enhances glutathione-dependent pathways (Farooq et al., 2012). Additionally, Spirulina modulates inflammatory cytokines and DNA repair mechanisms, offering protection against carcinogenic compounds in cigarette smoke (Mathew et al., 1995). Given its systemic protective properties and high bioavailability, Spirulina represents a potent, non-pharmacological tool to counteract the biochemical insults associated with smoking and alcohol abuse in India.